STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (263 aa)    
Predicted Functional Partners:
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.999
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family.
 
  
 0.998
apbA
Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. Has a strong preference for NADPH over NADH as the electron acceptor. Pantoate, ketoisovalerate, oxaloacetate, pyruvate, 3-hydroxypyruvate, alpha-ketoglutarate, alpha-ketobutyrate, and acetaldehyde cannot serve as substrates for reduction.
 
  
 0.993
STM2573
Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
   
 0.993
ilvE
Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine.
    
 0.944
ilvD
Dihydroxy-acid dehydratase. (SW:ILVD_SALTY); Belongs to the IlvD/Edd family.
     
 0.927
STM3531
Similar to E. coli putative dehydratase (AAC73372.1); Blastp hit to AAC73372.1 (655 aa), 39% identity in aa 86 - 578; Belongs to the IlvD/Edd family.
     
 0.914
panS
Putative Na+-dependent transporter; Transports ketopantoate, pantoate and, to a lesser extent, pantothenate into the cell. Can also transport a product of coenzyme A (CoA) degradation that serves as a precursor to CoA and enters the biosynthetic pathway between PanC and CoaBC. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
  
  
 0.904
folK
7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, PPPK; Similar to E. coli 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase (AAC73253.1); Blastp hit to AAC73253.1 (159 aa), 87% identity in aa 1 - 148.
 
  
 0.729
dfp
Flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
   
 0.712
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.