STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fhuDHydroxamate-dependent iron uptake; ABC superfamily (bind _prot); similar to E. coli hydroxamate-dependent iron uptake, cytoplasmic membrane component (AAC73263.1); Blastp hit to AAC73263.1 (296 aa), 82% identity in aa 1 - 296. (296 aa)    
Predicted Functional Partners:
fhuC
Hydroxymate-dependent iron transport; ABC superfamily (atp_bind); similar to E. coli ATP-binding component of hydroxymate-dependent iron transport (AAC73262.1); Blastp hit to AAC73262.1 (265 aa), 92% identity in aa 1 - 265.
 
 0.999
fhuB
Hydroxamate-dependent iron uptake; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane (By similarity). Involved in ferrioxamine-mediated iron(III) utilization.
 0.999
fhuA
Iron complex outermembrane recepter protein; Similar to E. coli outer membrane protein receptor for ferrichrome, colicin M, and phages T1, T5, and phi80 (AAC73261.1); Blastp hit to AAC73261.1 (747 aa), 68% identity in aa 1 - 747.
 
  
 0.979
foxA
Ferrioxamine receptor; Ferrioxamine binding and uptake, in association with the TonB protein; Belongs to the TonB-dependent receptor family.
 
  
 0.884
fepB
ABC superfamily (peri_perm); similar to E. coli ferric enterobactin (enterochelin) binding protein; periplasmic component (AAC73693.1); Blastp hit to AAC73693.1 (318 aa), 79% identity in aa 1 - 318.
  
  
 0.868
fepC
Enterobactin transporter; ABC superfamily (atp_bind); similar to E. coli ATP-binding component of ferric enterobactin transport (AAC73689.1); Blastp hit to AAC73689.1 (271 aa), 92% identity in aa 1 - 263.
 
 
 0.846
fhuF
Ferric hydrozamate transport protein; Involved in reduction of ferric iron in cytoplasmic ferrioxamine B; similar to E. coli orf, hypothetical protein (AAC77323.1); Blastp hit to AAC77323.1 (262 aa), 73% identity in aa 1 - 262.
 
  
 0.806
fhuE
Outer membrane receptor for Fe(III)-coprogen; Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid uptake; similar to E. coli outer membrane receptor for ferric iron uptake (AAC74186.1); Blastp hit to AAC74186.1 (729 aa), 81% identity in aa 5 - 729.
  
  
 0.748
iroE
Putative hydrolase of the alpha/beta superfamily.
 
  
 0.746
yhgG
Putative cytoplasmic protein; May function as a transcriptional regulator that controls feoABC expression.
      
 0.718
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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