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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dgtDeoxyguanosine triphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa)    
Predicted Functional Partners:
surE
Survival protein, protein damage control; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
 
  
 0.922
yrfG
Similar to E. coli putative phosphatase (AAC76424.1); Blastp hit to AAC76424.1 (237 aa), 85% identity in aa 16 - 237.
    
  0.903
yjjG
Putative haloacid dehalogenase-like hydrolase; Similar to E. coli putative phosphatase (AAC77327.1); Blastp hit to AAC77327.1 (225 aa), 91% identity in aa 1 - 225.
    
  0.903
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 
  0.901
ushA
UDP-sugar hydrolase 5'-nucleotidase; Silent protein USHA(0) precursor. (SW:USHA_SALTY); Belongs to the 5'-nucleotidase family.
     
  0.900
pykF
Pyruvate kinase I; Formerly F; fructose stimulated; pyruvate kinase I. (SW:KPY1_SALTY).
     
  0.900
pykA
Pyruvate kinase II; Glucose stimulated; similar to E. coli pyruvate kinase II, glucose stimulated (AAC74924.1); Blastp hit to AAC74924.1 (480 aa), 98% identity in aa 1 - 480.
     
  0.900
STM4104
Putative 5'-nucleotidase; Related esterase; similar to E. coli UDP-sugar hydrolase (5'-nucleotidase) (AAC73582.1); Blastp hit to AAC73582.1 (550 aa), 25% identity in aa 34 - 253, 28% identity in aa 383 - 506; 2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family.
     
  0.900
nrdD
Anaerobic ribonucleoside-triphosphate reductase; Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair. Belongs to the anaerobic ribonucleoside-triphosphate reductase family.
     
  0.900
deoD
Similar to E. coli purine-nucleoside phosphorylase (AAC77337.1); Blastp hit to AAC77337.1 (239 aa), 96% identity in aa 1 - 239.
     
  0.900
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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