Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gloBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (251 aa)    
Predicted Functional Partners:
gloA
Glyoxalase I; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
 
 0.998
gshB
Similar to E. coli glutathione synthetase (AAC75984.1); Blastp hit to AAC75984.1 (316 aa), 90% identity in aa 1 - 313.
 
   
 0.937
ldhA
Similar to E. coli fermentative D-lactate dehydrogenase, NAD-dependent (AAC74462.1); Blastp hit to AAC74462.1 (329 aa), 94% identity in aa 1 - 328; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.919
ycbL
Putative metallo-beta-lactamase; Similar to E. coli orf, hypothetical protein (AAC74013.1); Blastp hit to AAC74013.1 (215 aa), 91% identity in aa 1 - 215.
  
  
0.918
dld
NADH independent D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family.
    
 0.903
mgsA
Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
      
 0.860
thiJ
4-methyl-5(beta-hydroxyethyl)-thiazole synthesis; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, g [...]
     
 0.857
yafS
Putative SAM-dependent methyltransferase; Similar to E. coli orf, hypothetical protein (AAC73318.1); Blastp hit to AAC73318.1 (246 aa), 86% identity in aa 7 - 244.
     
 0.853
STM1561
Putative outer membrane or secreted lipoprotein.
 
      0.772
gshA
Glutamate--cysteine ligase. (SW:GSH1_SALTY); Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
   
  
 0.757
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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