STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yafKPutative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73328.1); Blastp hit to AAC73328.1 (246 aa), 90% identity in aa 1 - 246. (246 aa)    
Predicted Functional Partners:
erfK
Putative periplasmic protein; Protein ERKF/SRFK precursor. (SW:ERFK_SALTY); Belongs to the YkuD family.
 
  
 0.910
mrcB
Transpeptidase of penicillin-binding protein 1b; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
      
 0.899
ftsI-2
Putative penicillin-binding protein-3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
      
 0.898
ftsI
Division specific transpeptidase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
      
 0.897
mrdA
Cell elongation specific transpeptidase of penicillin-binding protein 2 (peptidoglycan synthetase); Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
      
 0.897
mrdA-2
Putative penicillin-binding protein; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
      
 0.897
ybiS
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73906.1); Blastp hit to AAC73906.1 (306 aa), 92% identity in aa 1 - 306.
 
  
 0.864
ftsW
Essential cell division gene; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.
      
 0.847
ftsN
Essential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
   
  
 0.834
ynhG
Putative LysM domain protein; Similar to E. coli orf, hypothetical protein (AAC74748.1); Blastp hit to AAC74748.1 (334 aa), 85% identity in aa 1 - 334.
 
  
 0.806
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.