STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yafAPutative hydrolase of the alpha/beta superfamily; Displays esterase activity toward pNP-butyrate. (414 aa)    
Predicted Functional Partners:
crl
Transcriptional regulator of cryptic csgA gene for curli surface fibers; Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes, such as the csgBAC operon encoding the subunits of curli proteins, and BcsA, involved in cellulose biosynthesis.
 
    0.872
yafD
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73314.1); Blastp hit to AAC73314.1 (266 aa), 96% identity in aa 8 - 266.
  
    0.740
ycbW
Putative cytoplasmic protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
  
     0.734
ycfP
Putative esterase; Similar to E. coli orf, hypothetical protein (AAC74192.1); Blastp hit to AAC74192.1 (199 aa), 94% identity in aa 20 - 199; Belongs to the UPF0227 family.
  
    0.727
mlc
Transcriptional repressor of ptsG and ptsHI; Global repressor of carbohydrate metabolism (pts operon) (NagC/XylR family); similar to E. coli putative NAGC-like transcriptional regulator (AAC74666.1); Blastp hit to AAC74666.1 (406 aa), 90% identity in aa 1 - 406.
  
   
 0.703
yaeH
Similar to E. coli putative structural protein (AAC73274.1); Blastp hit to AAC73274.1 (128 aa), 95% identity in aa 1 - 128; Belongs to the UPF0325 family.
  
     0.681
malP
Maltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
      
 0.660
cyaA
Adenylate cyclase. (SW:CYAA_SALTY).
  
   
 0.656
yieM
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76768.1); Blastp hit to AAC76768.1 (427 aa), 89% identity in aa 1 - 427.
  
     0.601
mltA
Membrane-bound lytic murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.
 
     0.596
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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