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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STM0343Putative diguanylate cyclase/phosphodiesterase domain 1; Similar to E. coli orf, hypothetical protein (AAC75237.1); Blastp hit to AAC75237.1 (518 aa), 31% identity in aa 10 - 512. (524 aa)    
Predicted Functional Partners:
yaiC
Putative diguanylate cyclase/phosphodiesterase domain 1; Similar to E. coli orf, hypothetical protein (AAC73488.1); Blastp hit to AAC73488.1 (371 aa), 75% identity in aa 1 - 371.
   
 0.975
yfiN
Putative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC75653.1); Blastp hit to AAC75653.1 (408 aa), 75% identity in aa 2 - 405.
    0.947
STM4551
Putative diguanylate cyclase/phosphodiesterase domain 1 containing protein; Similar to E. coli orf, hypothetical protein (AAC74110.1); Blastp hit to AAC74110.1 (452 aa), 41% identity in aa 274 - 444, 24% identity in aa 14 - 102.
  
 0.943
yeaJ
Putative methyl-accepting chemotaxis protein; Diguanylate cyclase/phosphodiesterase domain 1; similar to E. coli orf, hypothetical protein (AAC74856.1); Blastp hit to AAC74856.1 (556 aa), 68% identity in aa 61 - 556.
  
   
 0.915
STM2010
Putative cytoplasmic protein.
      
 0.836
STM0699
Putative cytoplasmic protein.
      
 0.801
dgcQ
Putative inner membrane protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity).
 
   
 0.779
STM4595
Putative fimbrial chaparone protein; Similar to E. coli fimbrial morphology (AAC77274.1); Blastp hit to AAC77274.1 (176 aa), 29% identity in aa 1 - 176.
      
 0.764
yhdA
Putative diguanylate cyclase; Similar to E. coli orf, hypothetical protein (AAC76284.1); Blastp hit to AAC76284.1 (646 aa), 84% identity in aa 1 - 646.
  
     0.742
tctD
Tricarboxylic transport regulatory protein; Transcriptional activator of the tctI tricarboxylate transport system operon.
  
   
 0.726
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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