STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STM0347Putative response regulator; Unknown (gi|6707275). (213 aa)    
Predicted Functional Partners:
STM0349
Putative outer membrane lipoprotein; Similar to E. coli orf, hypothetical protein (AAC77104.1); Blastp hit to AAC77104.1 (128 aa), 35% identity in aa 15 - 127.
  
  
 0.968
ygfY
Putative cytoplasmic protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
      
 0.857
STM0348
Putative inner membrane protein.
  
    0.793
yhcQ
Putative membrane located multidrug resistance protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.720
STM0346
Putative outer membrane protein; Unknown (gi|6707276).
  
    0.629
stbC
Putative fimbriae; Similar to E. coli outer membrane protein; export and assembly of type 1 fimbriae, interrupted (AAC77273.1); Blastp hit to AAC77273.1 (878 aa), 30% identity in aa 30 - 870.
   
  
 0.526
cheM
Methyl accepting chemotaxis protein II; Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar mediates taxis away from the repellents cobalt and nickel. Unlike in E.coli tar, it does not mediates maltose taxis.
      
 0.519
uhpA
Response regulator (repressor) in two-component regulatory system wtih UhpB; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region.
    
 
 0.486
gcvH
Glycine cleavage complex protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
      
 0.480
fimY
Putative regulatory protein; Fimbriae Y protein. (SW:FIMY_SALTY).
   
  
 0.463
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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