| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| STM0356 | mod | STM0356 | STM0357 | Similar to E. coli putative transport protein (AAC77235.1); Blastp hit to AAC77235.1 (425 aa), 28% identity in aa 33 - 412. | DNA methylase; Binds the system-specific DNA recognition site 5'-CAGAG-3'. Necessary for restriction and for methylation of A-4. | 0.453 |
| STM0356 | res | STM0356 | STM0358 | Similar to E. coli putative transport protein (AAC77235.1); Blastp hit to AAC77235.1 (425 aa), 28% identity in aa 33 - 412. | DNA restriction (DNA helicase); Cleaves DNA some 25 base-pairs downstream from the recognition site. May also act as a helicase involved in unwinding DNA at the cleavage site. Protein only required for restriction but needs the presence of the modification enzyme; Belongs to the type III restriction-modification system res protein family. | 0.453 |
| STM0926 | hsdR | STM0926 | STM4526 | Putative Fels-1 prophage minor tail protein; Similar to E. coli putative membrane protein (AAC74454.1); Blastp hit to AAC74454.1 (1122 aa), 50% identity in aa 3 - 515, 57% identity in aa 878 - 1084, 43% identity in aa 1008 - 1122, 34% identity in aa 354 - 568, 29-1073758628dentity in aa 116 - 346, 24% identity in aa 962 - 1111, 26-1073758654dentity in aa 940 - 1106, 27% identity in aa 420 - 581, 23% identity in aa 959 - 1113, 23% identity in aa 961 - 1079, 30% identity in aa 778 - 829, 22% identity in aa 778 - 850. | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | 0.476 |
| STM0926 | mod | STM0926 | STM0357 | Putative Fels-1 prophage minor tail protein; Similar to E. coli putative membrane protein (AAC74454.1); Blastp hit to AAC74454.1 (1122 aa), 50% identity in aa 3 - 515, 57% identity in aa 878 - 1084, 43% identity in aa 1008 - 1122, 34% identity in aa 354 - 568, 29-1073758628dentity in aa 116 - 346, 24% identity in aa 962 - 1111, 26-1073758654dentity in aa 940 - 1106, 27% identity in aa 420 - 581, 23% identity in aa 959 - 1113, 23% identity in aa 961 - 1079, 30% identity in aa 778 - 829, 22% identity in aa 778 - 850. | DNA methylase; Binds the system-specific DNA recognition site 5'-CAGAG-3'. Necessary for restriction and for methylation of A-4. | 0.451 |
| hepA | mod | STM0096 | STM0357 | RNA polymerase associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | DNA methylase; Binds the system-specific DNA recognition site 5'-CAGAG-3'. Necessary for restriction and for methylation of A-4. | 0.501 |
| hsdM | hsdR | STM4525 | STM4526 | DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | 0.999 |
| hsdM | hsdS | STM4525 | STM4524 | DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. | Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...] | 0.999 |
| hsdM | mod | STM4525 | STM0357 | DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. | DNA methylase; Binds the system-specific DNA recognition site 5'-CAGAG-3'. Necessary for restriction and for methylation of A-4. | 0.878 |
| hsdM | ydaL | STM4525 | STM1658 | DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. | Putative Smr domain protein; Similar to E. coli orf, hypothetical protein (AAC74422.1); Blastp hit to AAC74422.1 (187 aa), 86% identity in aa 1 - 187. | 0.859 |
| hsdM | yhdJ | STM4525 | STM3386 | DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. | Similar to E. coli putative methyltransferase (AAC76294.1); Blastp hit to AAC76294.1 (296 aa), 80% identity in aa 3 - 285; Belongs to the N(4)/N(6)-methyltransferase family. | 0.576 |
| hsdR | STM0926 | STM4526 | STM0926 | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | Putative Fels-1 prophage minor tail protein; Similar to E. coli putative membrane protein (AAC74454.1); Blastp hit to AAC74454.1 (1122 aa), 50% identity in aa 3 - 515, 57% identity in aa 878 - 1084, 43% identity in aa 1008 - 1122, 34% identity in aa 354 - 568, 29-1073758628dentity in aa 116 - 346, 24% identity in aa 962 - 1111, 26-1073758654dentity in aa 940 - 1106, 27% identity in aa 420 - 581, 23% identity in aa 959 - 1113, 23% identity in aa 961 - 1079, 30% identity in aa 778 - 829, 22% identity in aa 778 - 850. | 0.476 |
| hsdR | hsdM | STM4526 | STM4525 | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. | 0.999 |
| hsdR | hsdS | STM4526 | STM4524 | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...] | 0.998 |
| hsdR | mod | STM4526 | STM0357 | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | DNA methylase; Binds the system-specific DNA recognition site 5'-CAGAG-3'. Necessary for restriction and for methylation of A-4. | 0.711 |
| hsdR | res | STM4526 | STM0358 | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | DNA restriction (DNA helicase); Cleaves DNA some 25 base-pairs downstream from the recognition site. May also act as a helicase involved in unwinding DNA at the cleavage site. Protein only required for restriction but needs the presence of the modification enzyme; Belongs to the type III restriction-modification system res protein family. | 0.592 |
| hsdR | ydaL | STM4526 | STM1658 | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | Putative Smr domain protein; Similar to E. coli orf, hypothetical protein (AAC74422.1); Blastp hit to AAC74422.1 (187 aa), 86% identity in aa 1 - 187. | 0.451 |
| hsdS | hsdM | STM4524 | STM4525 | Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...] | DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. | 0.999 |
| hsdS | hsdR | STM4524 | STM4526 | Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...] | Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188. | 0.998 |
| hsdS | mod | STM4524 | STM0357 | Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...] | DNA methylase; Binds the system-specific DNA recognition site 5'-CAGAG-3'. Necessary for restriction and for methylation of A-4. | 0.754 |
| hsdS | ydaL | STM4524 | STM1658 | Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...] | Putative Smr domain protein; Similar to E. coli orf, hypothetical protein (AAC74422.1); Blastp hit to AAC74422.1 (187 aa), 86% identity in aa 1 - 187. | 0.860 |
