Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
resDNA restriction (DNA helicase); Cleaves DNA some 25 base-pairs downstream from the recognition site. May also act as a helicase involved in unwinding DNA at the cleavage site. Protein only required for restriction but needs the presence of the modification enzyme; Belongs to the type III restriction-modification system res protein family. (990 aa)    
Predicted Functional Partners:
mod
DNA methylase; Binds the system-specific DNA recognition site 5'-CAGAG-3'. Necessary for restriction and for methylation of A-4.
 
  
 0.984
yhdJ
Similar to E. coli putative methyltransferase (AAC76294.1); Blastp hit to AAC76294.1 (296 aa), 80% identity in aa 3 - 285; Belongs to the N(4)/N(6)-methyltransferase family.
     
 0.887
STM1010
Gifsy-2 prophage protein; Hypothetical protein 4 (gi|7467264).
   
  
 0.720
STM2631
Gifsy-1 prophage protein; Hypothetical protein 4 (gi|7467264).
   
  
 0.719
STM1056
Gifsy-2 prophage protein; Similar to msgA; hypothetical protein (gi|5410521).
      
 0.712
STM2636
Gifsy-1 prophage protein; Similar to integrase in phage; probable integrase (gi|7467280); Belongs to the 'phage' integrase family.
   
  
 0.651
hsdR
Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188.
  
  
 0.592
tnpA_3
Transposase for insertion sequence element is200 (SW:T200_SALTY).
      
 0.513
STM4495
Putative type II restriction enzyme, methylase subunit.
      
 0.475
STM0356
Similar to E. coli putative transport protein (AAC77235.1); Blastp hit to AAC77235.1 (425 aa), 28% identity in aa 33 - 412.
       0.453
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.