STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phoBRegulates pho regulon (OmpR family); similar to E. coli positive response regulator for pho regulon, sensor is PhoR (or CreC) (AAC73502.1); Blastp hit to AAC73502.1 (229 aa), 95% identity in aa 1 - 229. (229 aa)    
Predicted Functional Partners:
phoR
Sensory kinase in two-component regulatory system with PhoB, regulates pho regulon; Similar to E. coli positive and negative sensor protein for pho regulon (AAC73503.1); Blastp hit to AAC73503.1 (431 aa), 90% identity in aa 1 - 431.
 0.999
phoQ
Sensory kinase protein in two-component regulatory system with PhoP; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane- associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of [...]
 
 
 0.933
barA
Sensory histidine kinase; Similar to E. coli sensor-regulator, activates OmpR by phophorylation (AAC75828.1); Blastp hit to AAC75828.1 (918 aa), 90% identity in aa 1 - 918.
 
 
 0.925
phoU
Regulatory gene for high affinity phosphate uptake; Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions.
  
 0.911
envZ
Sensory histidine kinase in two-component regulatory system with OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). EnvZ functions as a membrane- associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity).
 
 0.897
arcB
Sensory histidine kinase in two-component regulatory system with ArcA; Senses redox conditions; similar to E. coli aerobic respiration sensor-response protein; histidine protein kinase/phosphatase, sensor for arcA (AAC76242.1); Blastp hit to AAC76242.1 (776 aa), 93% identity in aa 1 - 776.
 
 0.892
torS
Histidine kinase; Regulates tor operon; similar to E. coli sensor protein torS (regulator TorR) (AAC74078.1); Blastp hit to AAC74078.1 (904 aa), 62% identity in aa 1 - 896.
 
 
 0.876
cpxA
Sensory kinase in two-component regulatory system with CpxR; Senses misfolded proteins in bacterial envelope; similar to E. coli probable sensor protein (histidine protein kinase), acting on arcA (AAC76893.1); Blastp hit to AAC76893.1 (457 aa), 96% identity in aa 1 - 457.
 
 0.875
rstB
Sensory histidine kinase in two-component regulatory system with RstA; Similar to E. coli sensor histidine protein kinase (RstA regulator) (AAC74681.1); Blastp hit to AAC74681.1 (433 aa), 82% identity in aa 1 - 433.
 
 0.866
basS
Sensory kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.
 
 
 0.856
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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