Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
brnQLIVCS family, branched chain amino acid transporter system II (LIV-II); Component of the LIV-II transport system for branched-chain amino acids. This LIV-II transport system may be H(+)-coupled. (439 aa)    
Predicted Functional Partners:
yaaJ
AGCS family; similar to E. coli inner membrane transport protein (AAC73118.1); Blastp hit to AAC73118.1 (476 aa), 76% identity in aa 1 - 476.
  
   
 0.842
livJ
High-affinity branched-chain amino acid transporter; This protein is a component of the leucine, isoleucine, valine, threonine transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids; Belongs to the leucine-binding protein family.
   
  
 0.820
proY
Putative APC family, proline transporter; Permease that is involved in the transport across the cytoplasmic membrane of proline; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
 
  
 0.797
phoR
Sensory kinase in two-component regulatory system with PhoB, regulates pho regulon; Similar to E. coli positive and negative sensor protein for pho regulon (AAC73503.1); Blastp hit to AAC73503.1 (431 aa), 90% identity in aa 1 - 431.
      0.774
ygjU
Putative dicarboxylate permease; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
 
  
 0.768
ydgR
Putative POT family peptide transport protein; Proton-dependent permease that transports di- and tripeptides.
   
  
 0.719
cycA
APC family D-alanine/D-serine/glycine transport protein; Similar to E. coli transport of D-alanine, D-serine, and glycine (AAC77165.1); Blastp hit to AAC77165.1 (470 aa), 95% identity in aa 1 - 469.
  
  
 0.704
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
   
  
 0.635
ilvE
Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine.
      
 0.548
gltS
GltS family glutamate transport protein; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
 
  
 0.524
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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