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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phnR2-aminoethylphosphonate transport, repressor; Probable repressor protein of GntR family phnR (gi|11354257). (239 aa)    
Predicted Functional Partners:
phnX
2-aminoethylphosphonate transport; Involved in phosphonate degradation.
 
  
 0.971
phnW
2-aminoethylphosphonate transport; Involved in phosphonate degradation.
 
   
 0.963
phnB
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77068.1); Blastp hit to AAC77068.1 (147 aa), 83% identity in aa 1 - 145.
   
  
 0.899
phnS
2-aminoethylphosphonate transporter, periplasmic-binding component; Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import; Belongs to the bacterial solute-binding protein 1 family.
 
  
 0.854
nadR
Trifunctional protein; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the A [...]
   
  
 0.740
phnV
2-aminoethylphosphonate transporter, memrane component; Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family.
 
     0.739
phnU
2-aminoethylphosphonate transporter, memrane component; Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family.
 
    0.710
STM4068
Putative gntR family regulatory protein; Similar to E. coli transcriptional regulator of succinylCoA synthetase operon (AAC73824.1); Blastp hit to AAC73824.1 (240 aa), 28% identity in aa 5 - 220.
  
    0.708
hutC
Histidine utilization repressor; Similar to E. coli transcriptional regulator of succinylCoA synthetase operon (AAC73824.1); Blastp hit to AAC73824.1 (240 aa), 24% identity in aa 5 - 229.
  
     0.696
phnT
2-aminoethylphosphonate transporter ATPase component; Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for energy coupling to the transport system.
 
   0.628
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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