STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phnW2-aminoethylphosphonate transport; Involved in phosphonate degradation. (367 aa)    
Predicted Functional Partners:
phnX
2-aminoethylphosphonate transport; Involved in phosphonate degradation.
 
 0.999
phnO
Putative regulator in phn operon; Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including (S)-1- aminoethylphosphonate ((S)-1AEP) and 2-aminoethylphosphonate, using acetyl-CoA as acetyl donor. Its physiological role in S.typhimurium is unclear. However, by acetylating (S)-1AEP, PhnO would protect against the deleterious effects of (S)-1AEP, a structural analog of D-alanine that has antibacterial properties.
     
 0.989
phnR
2-aminoethylphosphonate transport, repressor; Probable repressor protein of GntR family phnR (gi|11354257).
 
   
 0.963
phnS
2-aminoethylphosphonate transporter, periplasmic-binding component; Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import; Belongs to the bacterial solute-binding protein 1 family.
 
  
 0.924
phnA
Putative alkylphosphonate uptake protein in phosphonate metabolism; Similar to E. coli orf, hypothetical protein (AAC77069.1); Blastp hit to AAC77069.1 (111 aa), 96% identity in aa 1 - 111.
      
 0.924
phnB
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77068.1); Blastp hit to AAC77068.1 (147 aa), 83% identity in aa 1 - 145.
      
 0.896
map
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
     
 0.893
STM3602
Putative gntR family regulatory protein; Similar to E. coli putative transcriptional regulator (AAC76400.1); Blastp hit to AAC76400.1 (265 aa), 28% identity in aa 27 - 260.
     
 0.676
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.659
purD
GAR synthetase; phosphoribosylamine--glycine ligase. (SW:PUR2_SALTY); Belongs to the GARS family.
  
    0.648
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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