STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ybaWPutative esterase; Similar to E. coli orf, hypothetical protein (AAC73546.1); Blastp hit to AAC73546.1 (132 aa), 94% identity in aa 1 - 132. (132 aa)    
Predicted Functional Partners:
tesB
Similar to E. coli acyl-CoA thioesterase II (AAC73555.1); Blastp hit to AAC73555.1 (286 aa), 91% identity in aa 1 - 286.
     
 0.896
ybaV
Putative DNA uptake protein and related DNA-binding proteins; Similar to E. coli orf, hypothetical protein (AAC73545.1); Blastp hit to AAC73545.1 (123 aa), 83% identity in aa 1 - 123.
 
    0.815
tesA
Similar to E. coli acyl-CoA thioesterase I; also functions as protease I (AAC73596.1); Blastp hit to AAC73596.1 (208 aa), 89% identity in aa 2 - 205.
   
  
 0.778
aas
2-acylglycerophospho-ethanolamine acyl transferase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
  
  
 0.568
yfcX
Putative dehydrogenase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
  
  
 0.556
fadH
2,4-dieonyl-coa reductase; Similar to E. coli putative NADPH dehydrogenase (AAC76116.1); Blastp hit to AAC76116.1 (672 aa), 85% identity in aa 1 - 672.
 
  
 0.553
fadR
Negative regulator of fad regulon; Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds (By similarity).
      
 0.531
cof
Putative hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P).
 
     0.506
fadB
3-hydroxyacyl-coA dehydrogenase of 4-enzyme FadB protein; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
  
  
 0.498
fabD
Malonyl coA-acyl carrier protein transacylase. (SW:FABD_SALTY); Belongs to the FabD family.
  
  
 0.483
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.