STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
amtBPutative Amt family, ammonium transport protein; Similar to E. coli probable ammonium transporter (AAC73554.1); Blastp hit to AAC73554.1 (428 aa), 92% identity in aa 1 - 428. (428 aa)    
Predicted Functional Partners:
glnK
Regulatory protein P-II 2; Nitrogen assimilation by glutamine synthetase; regulates GlnL (NRII) and GlnE (ATase); similar to E. coli nitrogen regulatory protein P-II 2 (AAC73553.1); Blastp hit to AAC73553.1 (112 aa), 97% identity in aa 1 - 112.
 
 0.999
glnB
Regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase); P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).
 
 0.999
glnA
Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
  
  
 0.951
glnD
Uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
 
   
 0.938
gltB
Similar to E. coli glutamate synthase, large subunit (AAC76244.1); Blastp hit to AAC76244.1 (1517 aa), 95% identity in aa 32 - 1517.
 
  
 0.926
glnL
Sensory histidine kinase/phosphatase NtrB; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.
 
 
 0.918
glnG
EBP family response regulator in two-component regulatory system with GlnL; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
   
  
 0.817
gltD
Similar to E. coli glutamate synthase, small subunit (AAC76245.1); Blastp hit to AAC76245.1 (472 aa), 95% identity in aa 1 - 472.
 
  
 0.808
gdhA
NADP-specific glutamate dehydrogenase; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.
  
  
 0.745
glnE
Adenylyl transferase for glutamine synthetase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal trans [...]
  
  
 0.646
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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