Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
acrBSimilar to E. coli acridine efflux pump (AAC73564.1); Blastp hit to AAC73564.1 (1049 aa), 94% identity in aa 1 - 1048. (1049 aa)    
Predicted Functional Partners:
acrA
Similar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 91% identity in aa 1 - 397; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 0.999
tolC
Outer membrane channel; Specific tolerance to colicin E1; segregation of daughter chromosomes; role in organic solvent tolerance; similar to E. coli outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (AAC76071.1); Blastp hit to AAC76071.1 (495 aa), 89% identity in aa 1 - 495.
 
 0.997
STM0350
Homology to outer membrane efflux protein; Similar to E. coli putative resistance protein (AAC73673.1); Blastp hit to AAC73673.1 (457 aa), 37% identity in aa 7 - 457.
 0.993
acrE
Similar to E. coli transmembrane protein affects septum formation and cell membrane permeability (AAC76297.1); Blastp hit to AAC76297.1 (385 aa), 88% identity in aa 1 - 380; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.957
acrR
Similar to E. coli acrAB operon repressor (AAC73566.1); Blastp hit to AAC73566.1 (215 aa), 87% identity in aa 1 - 214.
     
 0.933
yohG
Putative outer membrane efflux protein; Similar to E. coli putative channel/filament proteins (AAC75199.1); Blastp hit to AAC75199.1 (398 aa), 85% identity in aa 1 - 396.
 0.932
marA
AraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF.
   
  
 0.897
soxS
Transcriptional activator of superoxide response regulon; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity).
      
 0.895
STM0352
Similar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 31% identity in aa 38 - 383; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.873
gyrA
DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...]
      
 0.859
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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