Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
aefAPutative small-conductance mechanosensitive channel; Similar to E. coli putative alpha helix protein (AAC73567.1); Blastp hit to AAC73567.1 (1120 aa), 89% identity in aa 1 - 1117. (1120 aa)    
Predicted Functional Partners:
yfbK
Putative von Willebrand factor, vWF type A domain protein; Similar to E. coli orf, hypothetical protein (AAC75330.1); Blastp hit to AAC75330.1 (575 aa), 45% identity in aa 22 - 190.
      
 0.897
trkA
Trk system transport of potassium protein; Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD(+) and NADH. In Salmonella it is required for resistance to antimicrobial peptides.
   
  
 0.680
recC
Exonuclease V, subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzy [...]
  
   
 0.650
yecG
Putative universal stress protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family.
  
   
 0.600
ycdZ
Putative inner membrane protein; Hypothetical protein in phoH-csgG intergenic region. (SW:YCDZ_SALTY).
  
     0.594
ybiH
Putative transcriptional repressor (TetR/AcrR family); Similar to E. coli putative transcriptional regulator (AAC73883.1); Blastp hit to AAC73883.1 (227 aa), 85% identity in aa 5 - 227.
  
     0.569
acrR
Similar to E. coli acrAB operon repressor (AAC73566.1); Blastp hit to AAC73566.1 (215 aa), 87% identity in aa 1 - 214.
       0.543
zntB
Putative Zn transport protein; Mediates efflux of zinc ions.
 
   
 0.533
hcr
NADH oxidoreductase for hcp gene product; Similar to E. coli putative enzyme (AAC73959.1); Blastp hit to AAC73959.1 (322 aa), 90% identity in aa 1 - 322.
  
    0.528
dacC
Similar to E. coli D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6 (AAC73926.1); Blastp hit to AAC73926.1 (400 aa), 92% identity in aa 1 - 400; Belongs to the peptidase S11 family.
      
 0.519
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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