| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| STM0353 | copA | STM0353 | STM0498 | Similar to E. coli putative ATPase (AAC73586.1); Blastp hit to AAC73586.1 (834 aa), 42% identity in aa 99 - 831, 45% identity in aa 4 - 63. | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | 0.683 |
| STM0353 | cueO | STM0353 | STM0168 | Similar to E. coli putative ATPase (AAC73586.1); Blastp hit to AAC73586.1 (834 aa), 42% identity in aa 99 - 831, 45% identity in aa 4 - 63. | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | 0.404 |
| STM0353 | cueR | STM0353 | STM0499 | Similar to E. coli putative ATPase (AAC73586.1); Blastp hit to AAC73586.1 (834 aa), 42% identity in aa 99 - 831, 45% identity in aa 4 - 63. | Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | 0.776 |
| STM3650 | cueO | STM3650 | STM0168 | Putative periplasmic or exported protein. | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | 0.916 |
| STM3650 | cueR | STM3650 | STM0499 | Putative periplasmic or exported protein. | Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | 0.895 |
| copA | STM0353 | STM0498 | STM0353 | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | Similar to E. coli putative ATPase (AAC73586.1); Blastp hit to AAC73586.1 (834 aa), 42% identity in aa 99 - 831, 45% identity in aa 4 - 63. | 0.683 |
| copA | cueO | STM0498 | STM0168 | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | 0.748 |
| copA | cueR | STM0498 | STM0499 | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | 0.894 |
| copA | sodC-2 | STM0498 | STM1440 | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | Copper/zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | 0.876 |
| copA | yohL | STM0498 | STM3023 | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | Putative cytoplasmic protein; Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity); Belongs to the FrmR/RcnR family. | 0.527 |
| copA | zntA | STM0498 | STM3576 | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | P-type ATPase family; Pb/Cd/Zn/Hg transporting ATPase; similar to E. coli zinc-transporting ATPase (AAC76494.1); Blastp hit to AAC76494.1 (732 aa), 84% identity in aa 1 - 731. | 0.776 |
| cueO | STM0353 | STM0168 | STM0353 | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | Similar to E. coli putative ATPase (AAC73586.1); Blastp hit to AAC73586.1 (834 aa), 42% identity in aa 99 - 831, 45% identity in aa 4 - 63. | 0.404 |
| cueO | STM3650 | STM0168 | STM3650 | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | Putative periplasmic or exported protein. | 0.916 |
| cueO | copA | STM0168 | STM0498 | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | 0.748 |
| cueO | cueR | STM0168 | STM0499 | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | 0.969 |
| cueO | sodC-2 | STM0168 | STM1440 | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | Copper/zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | 0.723 |
| cueO | zntA | STM0168 | STM3576 | Putative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). | P-type ATPase family; Pb/Cd/Zn/Hg transporting ATPase; similar to E. coli zinc-transporting ATPase (AAC76494.1); Blastp hit to AAC76494.1 (732 aa), 84% identity in aa 1 - 731. | 0.880 |
| cueR | STM0353 | STM0499 | STM0353 | Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | Similar to E. coli putative ATPase (AAC73586.1); Blastp hit to AAC73586.1 (834 aa), 42% identity in aa 99 - 831, 45% identity in aa 4 - 63. | 0.776 |
| cueR | STM3650 | STM0499 | STM3650 | Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | Putative periplasmic or exported protein. | 0.895 |
| cueR | copA | STM0499 | STM0498 | Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions. | 0.894 |
