Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
sfbAPutative ABC-type transport system ATPase component/cell division protein; Similar to E. coli putative lipoprotein (AAC73308.1); Blastp hit to AAC73308.1 (271 aa), 37% identity in aa 14 - 258. (276 aa)    
Predicted Functional Partners:
sfbB
Putative ABC-type transport system ATPase component/cell division protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
 
 0.999
sfbC
Putative binding-protein-dependent transport systems inner membrane component; Similar to E. coli putative transport system permease protein (AAC73309.1); Blastp hit to AAC73309.1 (217 aa), 44% identity in aa 15 - 217.
 0.999
yaeE
Putative ABC superfamily (membrane) transport protein; Part of the binding-protein-dependent transport system for D- methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 0.996
abc
Putative ABC superfamily (atp_bind) transport system; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
 
 0.984
yaeC
Putative outer membrane lipoprotein; This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system.
  
 
 
0.920
osmX
Putative periplasmic component; Part of the OsmU ABC transporter complex, which is involved in the uptake of osmoprotectants such as choline-O-sulfate and glycine betaine.
   
  
 0.752
hilA
Invasion genes transcription activator; The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of InvF. Also binds upstream of prgH and directly activates the expression of prgHIJK operon.
      
 0.726
slyA
MarR family transcriptional regulator for hemolysin; Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.
   
  
 0.514
STM0509
Putative outer membrane protein.
       0.427
metF
5,10-methylenetetrahydrofolate reductase. (SW:METF_SALTY); Belongs to the methylenetetrahydrofolate reductase family.
  
  
 0.424
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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