STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
purEPhosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)    
Predicted Functional Partners:
purK
Phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 0.999
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.999
purC
SAICAR synthetase; similar to E. coli phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase (AAC75529.1); Blastp hit to AAC75529.1 (237 aa), 94% identity in aa 1 - 237.
 
 0.999
purM
AIR synthetase; similar to E. coli phosphoribosylaminoimidazole synthetase = AIR synthetase (AAC75552.1); Blastp hit to AAC75552.1 (345 aa), 91% identity in aa 1 - 345.
 
 
 0.999
purG
Phosphoribosylformylglycinamidine synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
 
 
 0.999
purD
GAR synthetase; phosphoribosylamine--glycine ligase. (SW:PUR2_SALTY); Belongs to the GARS family.
 
 0.999
purB
Similar to E. coli adenylosuccinate lyase (AAC74215.1); Blastp hit to AAC74215.1 (456 aa), 94% identity in aa 1 - 456.
  
 
 0.998
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional; bifunctional purine biosynthesis protein PURH. (SW:PUR9_SALTY); IMP cyclohydrolase.
 
  
 0.998
purN
Polyphosphate kinase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
  
 0.995
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.990
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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