Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
STM0561Sensor protein; Similar to E. coli putative 2-component sensor protein (AAC73671.1); Blastp hit to AAC73671.1 (480 aa), 74% identity in aa 375 - 479. (109 aa)    
Predicted Functional Partners:
copR
Copper resistance transcriptional regulatory protein; Pathogenicity island encoded protein: SPI5; similar to E. coli putative 2-component transcriptional regulator (AAC75035.1); Blastp hit to AAC75035.1 (239 aa), 74% identity in aa 6 - 236.
 
 0.947
basR
Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.
 
 0.820
ygiX
Putative transcriptional regulator; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of flhDC (By similarity).
 
 0.818
tctD
Tricarboxylic transport regulatory protein; Transcriptional activator of the tctI tricarboxylate transport system operon.
 
 0.816
cpxR
Response reguator in two-component regulatory system with CpxA; Regulates expression of protein folding and degrading factors (OmpR family); similar to E. coli transcriptional regulator in 2-component system (AAC76894.1); Blastp hit to AAC76894.1 (232 aa), 97% identity in aa 1 - 232.
 
 
 0.816
creB
Response regulator in two-component regulatory system with CreC; OmpR family; similar to E. coli catabolic regulation response regulator (AAC77351.1); Blastp hit to AAC77351.1 (229 aa), 83% identity in aa 1 - 229.
 
 
 0.816
phoP
Response regulator in two-component regulatory system with PhoQ; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repressio [...]
 
 0.815
phoB
Regulates pho regulon (OmpR family); similar to E. coli positive response regulator for pho regulon, sensor is PhoR (or CreC) (AAC73502.1); Blastp hit to AAC73502.1 (229 aa), 95% identity in aa 1 - 229.
 
 
 0.812
baeR
OmpR family; similar to E. coli transcriptional response regulatory protein (sensor BaeS) (AAC75140.1); Blastp hit to AAC75140.1 (240 aa), 96% identity in aa 1 - 240.
 
 0.811
torR
Two-component system, OmpR family, torCAD operon response regulator TorR; Regulates tor operon (TorR family); similar to E. coli response transcriptional regulator for torA (sensor TorS) (AAC74080.1); Blastp hit to AAC74080.1 (230 aa), 81% identity in aa 1 - 229.
 
 
 0.807
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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