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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STM0567Putative ATPase involved in DNA repair. (391 aa)    
Predicted Functional Partners:
nifU
NifU homolog; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.838
yhgI
Putative thioredoxin-like proteins and domain protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
 
 0.767
nifS
Putative aminotransferase class-V; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate; Belongs to the class-V pyridoxal-phosphate-dependent [...]
  
 
 0.550
yegD
Similar to E. coli putative heat shock protein (AAC75130.1); Blastp hit to AAC75130.1 (471 aa), 88% identity in aa 22 - 471.
  
 
 0.493
dnaK
Chaperone Hsp70; Acts as a chaperone.
  
 
 0.492
hscC
Putative heatshock protein, homolog of hsp70 in Hsc66 subfamily; Similar to E. coli putative dnaK protein (AAC73751.1); Blastp hit to AAC73751.1 (556 aa), 83% identity in aa 1 - 556; Belongs to the heat shock protein 70 family.
  
 
 0.492
hscA
Chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.
  
 
 0.492
yfhJ
Hypothetical protein; Believed to be involved in assembly of Fe-S clusters; similar to E. coli orf, hypothetical protein (AAC75577.1); Blastp hit to AAC75577.1 (66 aa), 92% identity in aa 1 - 66.
  
  
 0.414
yadR
Putative HesB-like domain protein; Required for insertion of 4Fe-4S clusters for at least IspG.
  
 
 0.413
sufA
Putative HesB-like domain protein; Similar to E. coli orf, hypothetical protein (AAC74754.1); Blastp hit to AAC74754.1 (122 aa), 84% identity in aa 1 - 122; Belongs to the HesB/IscA family.
  
 
 0.413
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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