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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dpiBSensory histidine kinase in two-component regulatory system with DpiA; Regulation of cit operon and plasmid inheritance genes; similar to E. coli putative sensor-type protein (AAC73720.1); Blastp hit to AAC73720.1 (552 aa), 86% identity in aa 2 - 552. (553 aa)    
Predicted Functional Partners:
dpiA
Response regulator in two-component regulatory system with DpiB; Transcriptional regulation of cit operon (citrate fermentation) genes and of plasmid inheritance genes (OmpR family); similar to E. coli sequence similarity to Shigella regulator (AAC73721.1); Blastp hit to AAC73721.1 (226 aa), 84% identity in aa 1 - 226.
 0.999
STM0052
Putative transcription regulator sensor for citrate; Similar to E. coli sequence similarity to Shigella regulator (AAC73721.1); Blastp hit to AAC73721.1 (226 aa), 47% identity in aa 5 - 223.
 0.986
STM0053
Putative transcription regulator; Histidine kinase for citrate; similar to E. coli putative sensor-type protein (AAC73720.1); Blastp hit to AAC73720.1 (552 aa), 42% identity in aa 12 - 538.
  
  
 
0.908
dcuR
Response regulator in two-component regulatory system with DcuS; Regulates anaerobic fumarate respiration; similar to E. coli putative 2-component transcriptional regulator (AAC77085.1); Blastp hit to AAC77085.1 (239 aa), 88% identity in aa 1 - 239.
 
 0.864
yjjI
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77333.1); Blastp hit to AAC77333.1 (516 aa), 89% identity in aa 1 - 516.
      
 0.838
yiaJ
IclR family transcriptional repressor; Similar to E. coli putative regulator (AAC76598.1); Blastp hit to AAC76598.1 (282 aa), 91% identity in aa 16 - 276.
  
   
 0.724
STM4351
Similar to E. coli arginine 3rd transport system periplasmic binding protein (AAC73947.1); Blastp hit to AAC73947.1 (243 aa), 57% identity in aa 1 - 243; Belongs to the bacterial solute-binding protein 3 family.
      
 0.718
ybaP
Putative cytoplasmic protein; Similar to E. coli putative ligase (AAC73584.1); Blastp hit to AAC73584.1 (264 aa), 66% identity in aa 1 - 264.
      
 0.700
yhcG
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76252.1); Blastp hit to AAC76252.1 (375 aa), 55% identity in aa 115 - 164.
   
  
 0.700
ybaK
Putative cytoplasmic protein; Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity.
      
 0.679
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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