STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ubiFPutative monooxygenase; Similar to E. coli orf, hypothetical protein (AAC73763.1); Blastp hit to AAC73763.1 (391 aa), 85% identity in aa 1 - 391. (391 aa)    
Predicted Functional Partners:
ubiG
3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
 
 0.997
ubiE
S-adenosylmethionine; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
  
 
 0.993
ubiA
P-hydroxybenzoate: octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
  
   
 0.961
yhbV
Putative protease; Similar to E. coli orf, hypothetical protein (AAC76193.1); Blastp hit to AAC76193.1 (298 aa), 91% identity in aa 1 - 298.
   
 
 0.915
yhbU
Similar to E. coli putative collagenase (AAC76192.1); Blastp hit to AAC76192.1 (331 aa), 96% identity in aa 1 - 331.
   
 
 0.911
yhbT
Putative lipid carrier protein; Similar to E. coli orf, hypothetical protein (AAC76191.1); Blastp hit to AAC76191.1 (174 aa), 90% identity in aa 1 - 174.
   
 
 0.906
yigP
Putative inner membrane protein; Required for ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex (By similarity). May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates (By similarity). Required for intracellular proliferation in macrophages. Belongs to the UbiJ family.
  
  
 0.879
sucB
2-oxoglutarate dehydrogenase (dihydrolipoyltranssuccinase E2 component); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
    
 
 0.732
yigC-2
Putative oxidoreductase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
      
 0.705
yqiC
Putative cytoplasmic protein; Required for efficient ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both. Dispensable for ubiquinone biosynthesis under anaerobiosis. Required for proliferation in macrophages and virulence in mice. Significantly contributes to colonization and invasion as well as host inflammation and innate immunity after infection. In vitro, has membrane fusogenic activity at acidic pH.
  
   
 0.651
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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