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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
citACitrate-proton symporter; Uptake of citrate across the boundary membrane with the concomitant transport of protons into the cell (symport system) (Probable). Allows the utilization of citrate as a sole source of carbon and energy upon expression in E.coli. Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. (434 aa)    
Predicted Functional Partners:
citB
Citrate utilization protein B. (SW:CIT2_SALTY).
  
  
 0.963
dcuS
Sensory histidine kinase in two-component retgulatory system with DcuR; Senses fumarate/C4-dicarboxylate; similar to E. coli putative 2-component sensor protein (AAC77086.1); Blastp hit to AAC77086.1 (543 aa), 81% identity in aa 1 - 542.
      
 0.833
STM0691
Putative periplasmic protein.
  
    0.678
citC2
Putative citrate lyase synthetase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
      
 0.670
STM1132
Similar to E. coli putative transport protein (AAC77235.1); Blastp hit to AAC77235.1 (425 aa), 57% identity in aa 25 - 418.
  
    0.656
STM2179
Putative sugar transporter; Similar to E. coli putative transport protein (AAC73456.1); Blastp hit to AAC73456.1 (418 aa), 43% identity in aa 35 - 207, 40% identity in aa 220 - 380, 27% identity in aa 62 - 200.
  
    0.618
phoQ
Sensory kinase protein in two-component regulatory system with PhoP; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane- associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of [...]
      
 0.578
rpmE2
Putative 50S ribosomal protein L31 (second copy); Similar to E. coli putative ribosomal protein (AAC73399.1); Blastp hit to AAC73399.1 (87 aa), 74% identity in aa 1 - 86.
   
    0.523
STM2342
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77150.1); Blastp hit to AAC77150.1 (484 aa), 27% identity in aa 30 - 483.
   
    0.518
rpmJ2
Putative 50S ribosomal protein L36 (second copy); Belongs to the bacterial ribosomal protein bL36 family.
   
    0.495
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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