Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ybfELexA regulated, putative SOS response; Similar to E. coli orf, hypothetical protein (AAC73779.1); Blastp hit to AAC73779.1 (120 aa), 90% identity in aa 24 - 120. (97 aa)    
Predicted Functional Partners:
fldA
Flavodoxin 1; Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase; Belongs to the flavodoxin family.
 
  
 0.950
fur
Transcriptional repressor of iron-responsive genes (Fur family) (ferric uptake regulator); Similar to E. coli negative regulator (AAC73777.1); Blastp hit to AAC73777.1 (148 aa), 99% identity in aa 1 - 146; Belongs to the Fur family.
      0.827
ilvM
Similar to E. coli acetolactate synthase II, valine insensitive, small subunit (AAC77489.1); Blastp hit to AAC77489.1 (87 aa), 93% identity in aa 2 - 87.
  
     0.773
seqA
Negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
 
    0.743
gsk
Similar to E. coli inosine-guanosine kinase (AAC73579.1); Blastp hit to AAC73579.1 (434 aa), 94% identity in aa 1 - 434.
  
     0.738
yeaL
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC74859.1); Blastp hit to AAC74859.1 (148 aa), 94% identity in aa 1 - 130.
   
  
 0.730
ybeU
Putative cytoplasmic protein; Similar to E. coli putative tRNA ligase (AAC73749.1); Blastp hit to AAC73749.1 (235 aa), 61% identity in aa 1 - 235.
      
 0.724
yciW
Putative cytoplasmic protein; Similar to E. coli putative oxidoreductase (AAC74369.1); Blastp hit to AAC74369.1 (401 aa), 51% identity in aa 27 - 350.
      
 0.722
yacH
Similar to E. coli putative membrane protein (AAC73228.1); Blastp hit to AAC73228.1 (617 aa), 29% identity in aa 3 - 523.
      
 0.700
yeiG
Putative esterase; Serine hydrolase involved in the detoxification of formaldehyde.
      
 0.696
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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