Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
acrZPutative outer membrane or exported; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. (49 aa)    
Predicted Functional Partners:
ybgT
Putative outer membrane lipoprotein.
   
  
 0.905
tolC
Outer membrane channel; Specific tolerance to colicin E1; segregation of daughter chromosomes; role in organic solvent tolerance; similar to E. coli outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (AAC76071.1); Blastp hit to AAC76071.1 (495 aa), 89% identity in aa 1 - 495.
    
 
 0.890
acrA
Similar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 91% identity in aa 1 - 397; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
    
 
 0.850
ypeC
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75449.1); Blastp hit to AAC75449.1 (108 aa), 91% identity in aa 1 - 108.
      
 0.768
acrB
Similar to E. coli acridine efflux pump (AAC73564.1); Blastp hit to AAC73564.1 (1049 aa), 94% identity in aa 1 - 1048.
    
 
 0.732
yajC
Preprotein translocase IISP family, membrane subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
      
 0.675
yeaQ
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC74865.1); Blastp hit to AAC74865.1 (82 aa), 95% identity in aa 1 - 82.
   
  
 0.643
yhcC
Putative FeS oxidoreductase; Similar to E. coli orf, hypothetical protein (AAC76243.1); Blastp hit to AAC76243.1 (309 aa), 94% identity in aa 1 - 307.
      
 0.643
ybjP
Similar to E. coli putative enzyme (AAC73952.1); Blastp hit to AAC73952.1 (171 aa), 84% identity in aa 1 - 171.
    
   0.635
modE
Transcriptional repressor of modABCD operon (molybdate uptake); Similar to E. coli molybdate uptake regulatory protein (AAC73848.1); Blastp hit to AAC73848.1 (262 aa), 89% identity in aa 1 - 262.
       0.617
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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