STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Coexpression
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[Homology]
Score
mntRPutative Mn-dependent transcriptional regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Belongs to the DtxR/MntR family. (157 aa)    
Predicted Functional Partners:
mntH
Manganese/divalent cation transport protein; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake; Belongs to the NRAMP family.
 
  
 0.976
yebN
Putative YebN family transport protein; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family.
 
   
 0.973
ybiR
Putative di- and tricarboxylate transporters; Similar to E. coli orf, hypothetical protein (AAC73905.1); Blastp hit to AAC73905.1 (372 aa), 83% identity in aa 1 - 370.
 
    0.938
sitA
Fur regulated Salmonella iron transporter; SitA (gi|5231094); Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.904
zntR
MerR family; similar to E. coli putative transcriptional regulator (AAC76317.1); Blastp hit to AAC76317.1 (141 aa), 92% identity in aa 1 - 141.
      
 0.871
yohL
Putative cytoplasmic protein; Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity); Belongs to the FrmR/RcnR family.
      
 0.862
lepB
Leader peptidase (signal peptidase I), serine protease; Signal peptidase I. (SW:LEP_SALTY); Belongs to the peptidase S26 family.
   
    0.842
nikR
Nickel-responsive transcriptional regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
     
 0.837
cueR
Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations.
      
 0.814
ygiE
Putative divalent heavy-metal cations transporter; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions (By similarity); Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
  
  
 0.814
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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