| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gyrA | marA | STM2272 | STM1519 | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...] | AraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.852 |
| gyrA | mdaA | STM2272 | STM0874 | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...] | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | 0.705 |
| marA | gyrA | STM1519 | STM2272 | AraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...] | 0.852 |
| marA | mdaA | STM1519 | STM0874 | AraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | 0.656 |
| marA | ybjC | STM1519 | STM0873 | AraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC73937.1); Blastp hit to AAC73937.1 (95 aa), 59% identity in aa 1 - 95. | 0.500 |
| mdaA | gyrA | STM0874 | STM2272 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...] | 0.705 |
| mdaA | marA | STM0874 | STM1519 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | AraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.656 |
| mdaA | nemA | STM0874 | STM1436 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365. | 0.908 |
| mdaA | nfnB | STM0874 | STM0578 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity). | 0.996 |
| mdaA | rimK | STM0874 | STM0875 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | Ribosomal protein S6 modification protein; Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH. Belongs to the RimK family. | 0.894 |
| mdaA | umuC | STM0874 | STM1997 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | Error-prone repair protein; Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template. | 0.723 |
| mdaA | xapA | STM0874 | STM2422 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.664 |
| mdaA | ybjC | STM0874 | STM0873 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC73937.1); Blastp hit to AAC73937.1 (95 aa), 59% identity in aa 1 - 95. | 0.982 |
| mdaA | ybjN | STM0874 | STM0876 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | Putative cytoplasmic protein; Similar to E. coli putative sensory transduction regulator (AAC73940.1); Blastp hit to AAC73940.1 (158 aa), 84% identity in aa 1 - 158. | 0.700 |
| mdaA | ycaO | STM0874 | STM0975 | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73991.1); Blastp hit to AAC73991.1 (589 aa), 93% identity in aa 4 - 589. | 0.606 |
| nemA | mdaA | STM1436 | STM0874 | Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365. | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | 0.908 |
| nemA | nfnB | STM1436 | STM0578 | Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365. | Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity). | 0.921 |
| nfnB | mdaA | STM0578 | STM0874 | Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity). | Oxygen-insensitive NADPH nitroreductase; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. | 0.996 |
| nfnB | nemA | STM0578 | STM1436 | Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity). | Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365. | 0.921 |
| nfnB | ycaO | STM0578 | STM0975 | Dihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity). | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73991.1); Blastp hit to AAC73991.1 (589 aa), 93% identity in aa 4 - 589. | 0.606 |
