Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
nanHSialidase; Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections. (412 aa)    
Predicted Functional Partners:
STM0898
Predicted Fels-1 prophage transcriptional regulator.
   
    0.991
STM0893
Putative Fels-1 prophage integrase; Similar to E. coli putative transposase (AAC74651.1); Blastp hit to AAC74651.1 (398 aa), 55% identity in aa 2 - 398; Belongs to the 'phage' integrase family.
   
    0.968
STM0913
Fels-1 prophage protein.
   
    0.966
STM0035
Similar to E. coli putative sulfatase (AAC76701.1); Blastp hit to AAC76701.1 (497 aa), 26% identity in aa 2 - 420.
  
 
  0.957
STM0921
Putative Fels-1 prophage minor tail protein.
   
    0.941
STM3122
Similar to E. coli putative sulfatase (AAC74571.1); Blastp hit to AAC74571.1 (571 aa), 27% identity in aa 120 - 327, 43% identity in aa 322 - 358, 37% identity in aa 44 - 86, 31% identity in aa 435 - 471.
  
 
  0.938
STM0903
Putative Fels-1 prophage chaparone; Similar to E. coli orf, hypothetical protein (AAC74632.1); Blastp hit to AAC74632.1 (260 aa), 38% identity in aa 11 - 130, 37% identity in aa 152 - 259, 35% identity in aa 121 - 165, 58% identity in aa 123 - 134, 40-1073758628dentity in aa 168 - 187.
   
    0.923
nanA
N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
 
   
 0.922
melA
Alpha-galactosidase. (SW:AGAL_SALTY); Belongs to the glycosyl hydrolase 4 family.
     
 0.921
STM0918
Putative Fels-1 prophage minor tail protein; Lambda phage H tail component homolog (gi|2232364).
  
    0.920
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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