STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nanHSialidase; Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections. (412 aa)    
Predicted Functional Partners:
STM0898
Predicted Fels-1 prophage transcriptional regulator.
   
    0.992
STM0893
Putative Fels-1 prophage integrase; Similar to E. coli putative transposase (AAC74651.1); Blastp hit to AAC74651.1 (398 aa), 55% identity in aa 2 - 398; Belongs to the 'phage' integrase family.
   
    0.963
STM0913
Fels-1 prophage protein.
   
    0.961
nanA
N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
 
   
 0.953
melA
Alpha-galactosidase. (SW:AGAL_SALTY); Belongs to the glycosyl hydrolase 4 family.
     
 0.943
STM0921
Putative Fels-1 prophage minor tail protein.
   
    0.936
STM0903
Putative Fels-1 prophage chaparone; Similar to E. coli orf, hypothetical protein (AAC74632.1); Blastp hit to AAC74632.1 (260 aa), 38% identity in aa 11 - 130, 37% identity in aa 152 - 259, 35% identity in aa 121 - 165, 58% identity in aa 123 - 134, 40-1073758628dentity in aa 168 - 187.
   
    0.920
nanE
Putative ManNAc-6P epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
 
   
 0.919
STM0918
Putative Fels-1 prophage minor tail protein; Lambda phage H tail component homolog (gi|2232364).
  
    0.918
STM0900
Putative Fels-1 prophage DNA or RNA helicases of superfamily II; Similar to E. coli putative ATP-dependent helicase (AAC75245.1); Blastp hit to AAC75245.1 (586 aa), 29% identity in aa 124 - 378, 25% identity in aa 20 - 158.
   
    0.914
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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