STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpASimilar to E. coli ATP-binding component of serine protease (AAC73969.1); Blastp hit to AAC73969.1 (758 aa), 97% identity in aa 1 - 758; Belongs to the ClpA/ClpB family. (758 aa)    
Predicted Functional Partners:
yljA
Putative cytoplasmic protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
 
 0.999
clpP
Proteolytic subunit of clpA-clpP ATP-dependent serine protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.989
clpX
Specificity component of clpA-clpP ATP-dependent serine protease, chaperone; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
  
 
 0.932
dnaK
Chaperone Hsp70; Acts as a chaperone.
 
 
 0.835
cbpA
Curved DNA-binding protein; DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM.
  
 
 0.768
STM0912
Fels-1 prophage protease subunits of ATP-dependent proteases; Similar to E. coli ATP-dependent proteolytic subunit of clpA-clpP serine protease; ClpP family members; heat shock protein F21.5 (AAC73540.1); Blastp hit to AAC73540.1 (207 aa), 29% identity in aa 73 - 203; Belongs to the peptidase S14 family.
   
 
 0.764
STM1033
Gifsy-2 prophage Clp protease-like protein; Similar to E. coli ATP-dependent proteolytic subunit of clpA-clpP serine protease, heat shock protein F21.5 (AAC73540.1); Blastp hit to AAC73540.1 (207 aa), 29% identity in aa 73 - 203; Belongs to the peptidase S14 family.
   
 
 0.764
ssrA
Secretion system regulator: Sensor component; SpiR (gi|1498305).
  
 
 
 0.755
barA
Sensory histidine kinase; Similar to E. coli sensor-regulator, activates OmpR by phophorylation (AAC75828.1); Blastp hit to AAC75828.1 (918 aa), 90% identity in aa 1 - 918.
 
 
 
 0.753
ibpB
Small heat shock protein; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
 
 
 0.748
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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