Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
STM1043Attachment and invasion protein homolog (gi|2232362). (165 aa)    
Predicted Functional Partners:
STM2750
Similar to E. coli PTS system, glucitol/sorbitol-specific IIC component, one of two (AAC75744.1); Blastp hit to AAC75744.1 (187 aa), 40% identity in aa 9 - 162.
   
  
 0.951
STM2740
Fels-2 prophage protein; Similar to int protein in phage CP4-57; similar to E. coli prophage CP4-57 integrase (AAC75670.1); Blastp hit to AAC75670.1 (413 aa), 47% identity in aa 1 - 341; Belongs to the 'phage' integrase family.
   
  
 0.897
STM3260
Similar to E. coli PTS system galactitol-specific enzyme IIC (AAC75153.1); Blastp hit to AAC75153.1 (451 aa), 85% identity in aa 1 - 446.
      
 0.896
STM2759
Putative dipeptide/oligopeptide/nickel ABC-type transport systems, periplasmic component; Similar to E. coli putative transport protein (AAC73180.1); Blastp hit to AAC73180.1 (551 aa), 27% identity in aa 19 - 545.
   
  
 0.775
gogB
Gifsy-1 prophage leucine-rich repeat protein.
   
  
 0.760
sseI
Gifsy-2 prophage putative type III secreted protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.
      
 0.679
STM1042
Gifsy-2 prophage probable minor tail protein; Lambda phage M tail component homolog (gi|2232363).
  
    0.652
stdA
Similar to E. coli putative fimbrial-like protein (AAC73813.1); Blastp hit to AAC73813.1 (188 aa), 32% identity in aa 8 - 187.
      
 0.649
STM1041
Gifsy-2 prophage probable minor tail protein; Lambda phage H tail component homolog (gi|2232364).
  
    0.625
STM1036
Gifsy-2 prophage probable minor tail protein.
  
    0.615
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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