Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
STM1132Similar to E. coli putative transport protein (AAC77235.1); Blastp hit to AAC77235.1 (425 aa), 57% identity in aa 25 - 418. (426 aa)    
Predicted Functional Partners:
STM1133
Putative dehydrogenases and related proteins; Similar to E. coli putative dehydrogenase (AAC77236.1); Blastp hit to AAC77236.1 (377 aa), 62% identity in aa 6 - 371.
  
  
 0.986
nanM
Putative inner membrane protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family.
 
  
 0.936
STM1131
Putative outer membrane protein; Similar to E. coli orf, hypothetical protein (AAC77267.1); Blastp hit to AAC77267.1 (241 aa), 26% identity in aa 4 - 239.
  
  
 0.922
yggU
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75990.1); Blastp hit to AAC75990.1 (100 aa), 90% identity in aa 5 - 98; Belongs to the UPF0235 family.
      
 0.670
citA
Citrate-proton symporter; Uptake of citrate across the boundary membrane with the concomitant transport of protons into the cell (symport system) (Probable). Allows the utilization of citrate as a sole source of carbon and energy upon expression in E.coli. Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
  
    0.658
STM3600
Putative sugar kinases; Ribokinase family; similar to E. coli putative kinase (AAC76399.1); Blastp hit to AAC76399.1 (261 aa), 30% identity in aa 7 - 261.
   
  
 0.643
STM4412
Putative pemease; Similar to E. coli D-galactonate transport (AAC76714.1); Blastp hit to AAC76714.1 (445 aa), 31% identity in aa 42 - 197, 21% identity in aa 257 - 442.
  
    0.593
STM2274
Similar to E. coli putative transport protein (AAC75306.1); Blastp hit to AAC75306.1 (442 aa), 30% identity in aa 18 - 428.
  
    0.575
hpaX
4-hydroxyphenylacetate catabolism protein; Similar to E. coli putative transport protein (AAC75306.1); Blastp hit to AAC75306.1 (442 aa), 31% identity in aa 22 - 428.
  
    0.480
preT
Putative NADPH-dependent glutamate synthase beta chain or related oxidoreductase; Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity).
   
  
 0.456
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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