Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
csgDPutative transcriptional regulator; Necessary for transcription of the csgAB operon. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription (By similarity). (216 aa)    
Predicted Functional Partners:
csgF
Curli production assembly/transport component, 2nd curli operon; May be involved in the biogenesis of curli organelles.
 
  
 0.999
csgE
Curli production assembly/transport component, 2nd curli operon; May be involved in the biogenesis of curli organelles.
  
  
 0.999
csgG
Putative transcriptional regulator in curly assembly/transport, 2nd curli operon; May be involved in the biogenesis of curli organelles; Belongs to the CsgG family.
 
  
 0.996
csgB
Minor curlin subunit precursor; Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers; Belongs to the CsgA/CsgB family.
 
  
 0.965
csgA
Curlin major subunit; Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin; Belongs to the CsgA/CsgB family.
   
  
 0.959
yehV
Putative transcriptional repressor (MerR family); Transcriptional activator of csgD, which is required for production of the curli (AgF).
      
 0.950
uhpA
Response regulator (repressor) in two-component regulatory system wtih UhpB; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region.
  
   
 0.918
yhjO
Glycosyltransferase; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix.
   
  
 0.917
dgcQ
Putative inner membrane protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity).
  
  
 0.915
yegE
Putative PAS/PAC domain protein; Diguanylate cyclase/phosphodiesterase domain 1 and Diguanylate cyclase/phosphodiesterase domain 2 containing; similar to E. coli putative sensor-type protein (AAC75128.1); Blastp hit to AAC75128.1 (1105 aa), 76% identity in aa 540 - 437.
 
 
 0.915
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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