STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
csgCPutative curli production protein; Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation- precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity); Belongs to the CsgC/AgfC family. (108 aa)    
Predicted Functional Partners:
csgA
Curlin major subunit; Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin; Belongs to the CsgA/CsgB family.
  
  
 0.982
csgG
Putative transcriptional regulator in curly assembly/transport, 2nd curli operon; May be involved in the biogenesis of curli organelles; Belongs to the CsgG family.
   
  
 0.968
csgF
Curli production assembly/transport component, 2nd curli operon; May be involved in the biogenesis of curli organelles.
   
  
 0.968
csgE
Curli production assembly/transport component, 2nd curli operon; May be involved in the biogenesis of curli organelles.
   
  
 0.968
csgB
Minor curlin subunit precursor; Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers; Belongs to the CsgA/CsgB family.
     
 0.951
csgD
Putative transcriptional regulator; Necessary for transcription of the csgAB operon. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription (By similarity).
   
  
 0.900
ymdA
Putative periplasmic protein; Hypothetical protein in csgC-mdoG intergenic region precursor. (SW:YMDA_SALTY); To the N-terminal of the FimA/PapA family of fimbria proteins.
  
  
 0.615
dsbD
Thiol:disulfide interchange protein; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.
      
 0.459
yciK
Putative oxoacyl-(acyl carrier protein) reductase; Similar to E. coli putative oxidoreductase (AAC74353.1); Blastp hit to AAC74353.1 (252 aa), 88% identity in aa 1 - 252.
      
 0.450
invA
Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
      
 0.433
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.