Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dinIDNA damage-inducible protein I; Inhibits UmuD processing; similar to E. coli damage-inducible protein I (AAC74145.1); Blastp hit to AAC74145.1 (81 aa), 85% identity in aa 1 - 81. (81 aa)    
Predicted Functional Partners:
STM1022
Gifsy-2 prophage putative molecular chaperone, DnaJ family; Similar to E. coli orf, hypothetical protein (AAC74632.1); Blastp hit to AAC74632.1 (260 aa), 31% identity in aa 11 - 260.
      
 0.897
STM0777
Putative inner membrane protein.
      
 0.895
lexA
SOS response regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
  
 0.872
oraA
Regulator; Modulates RecA activity; Belongs to the RecX family.
   
  
 0.855
recA
DNA strand exchange and recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
   
 
 0.843
yceL
Putative MFS superfamily transport protein; Similar to E. coli orf, hypothetical protein (AAC74149.1); Blastp hit to AAC74149.1 (412 aa), 92% identity in aa 11 - 412.
      0.762
STM0038
Putative arylsulfatase.
      
 0.749
yebG
DNA damage-inducible gene in SOS regulon, dependent on cyclic AMP and H-NS; Similar to E. coli orf, hypothetical protein (AAC74918.1); Blastp hit to AAC74918.1 (96 aa), 79% identity in aa 1 - 96.
   
  
 0.727
recN
Protein used in recombination and DNA repair; May be involved in recombinational repair of damaged DNA.
   
  
 0.722
pyrC
Dihydro-orotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
      0.720
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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