STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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nagZPutative glycosyl hydrolase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Plays a role in beta-lactam antibiotic resistance via its role in generating anhydro-N-acetylmuramic acid-linked peptides; these peptides function as signaling molecules that induce high-level expression of the beta-lactamase AmpC; Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (341 aa)    
Predicted Functional Partners:
ampD
N-acetyl-anhydromuramyl-L-alanine amidase; Involved in cell wall peptidoglycan recycling. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
 
  
 0.978
ampG
MFS family, muropeptide transporter; Similar to E. coli regulates beta-lactamase synthesis (AAC73536.1); Blastp hit to AAC73536.1 (491 aa), 91% identity in aa 1 - 490.
 
  
 0.975
ydhH
Putative cytoplasmic protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.
 
 
 0.970
yfeW
Similar to E. coli putative beta-lactamase (AAC75483.1); Blastp hit to AAC75483.1 (463 aa), 72% identity in aa 30 - 461; Belongs to the peptidase S12 family. YfeW subfamily.
  
 0.944
mpl
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.
  
   
 0.877
ycfN
Putative cytoplasmic protein; Catalyzes the phosphorylation of thiamine to thiamine phosphate.
  
    0.839
ycfM
Putative outer membrane lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
  
    0.831
ycfL
Putative outer membrane lipoprotein; Similar to E. coli orf, hypothetical protein (AAC74188.1); Blastp hit to AAC74188.1 (125 aa), 80% identity in aa 1 - 125.
  
  
 0.824
ycfP
Putative esterase; Similar to E. coli orf, hypothetical protein (AAC74192.1); Blastp hit to AAC74192.1 (199 aa), 94% identity in aa 20 - 199; Belongs to the UPF0227 family.
  
  
 0.801
ycfF
Putative protein kinase C inhibitor; Similar to E. coli orf, hypothetical protein (AAC74187.1); Blastp hit to AAC74187.1 (119 aa), 97% identity in aa 1 - 119.
  
  
 0.798
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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