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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ycfPPutative esterase; Similar to E. coli orf, hypothetical protein (AAC74192.1); Blastp hit to AAC74192.1 (199 aa), 94% identity in aa 20 - 199; Belongs to the UPF0227 family. (180 aa)    
Predicted Functional Partners:
ycfM
Putative outer membrane lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
 
  
 0.826
ycfF
Putative protein kinase C inhibitor; Similar to E. coli orf, hypothetical protein (AAC74187.1); Blastp hit to AAC74187.1 (119 aa), 97% identity in aa 1 - 119.
  
  
 0.803
ycfL
Putative outer membrane lipoprotein; Similar to E. coli orf, hypothetical protein (AAC74188.1); Blastp hit to AAC74188.1 (125 aa), 80% identity in aa 1 - 125.
     
 0.800
nagZ
Putative glycosyl hydrolase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Plays a role in beta-lactam antibiotic resistance via its role in generating anhydro-N-acetylmuramic acid-linked peptides; these peptides function as signaling molecules that induce high-level expression of the beta-lactamase AmpC; Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
  
  
 0.795
ycfN
Putative cytoplasmic protein; Catalyzes the phosphorylation of thiamine to thiamine phosphate.
  
  
 0.783
yafA
Putative hydrolase of the alpha/beta superfamily; Displays esterase activity toward pNP-butyrate.
  
    0.727
ycbW
Putative cytoplasmic protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
  
     0.726
yieM
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76768.1); Blastp hit to AAC76768.1 (427 aa), 89% identity in aa 1 - 427.
  
     0.707
ilvM
Similar to E. coli acetolactate synthase II, valine insensitive, small subunit (AAC77489.1); Blastp hit to AAC77489.1 (87 aa), 93% identity in aa 2 - 87.
  
     0.649
yaeH
Similar to E. coli putative structural protein (AAC73274.1); Blastp hit to AAC73274.1 (128 aa), 95% identity in aa 1 - 128; Belongs to the UPF0325 family.
  
    0.636
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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