Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
aadAAminoglycoside adenyltransferase; Mediates bacterial resistance to the antibiotics streptomycin and spectomycin. (262 aa)    
Predicted Functional Partners:
rpsL
30S ribosomal subunit protein S12; With S4 and S5 plays an important role in translational accuracy.
      
 0.855
yjaB
Putative acetyltransferase; N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins; Belongs to the acetyltransferase family.
 
    
 0.771
folP
7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
     
 0.732
yjgK
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77209.1); Blastp hit to AAC77209.1 (153 aa), 80% identity in aa 4 - 153.
      
 0.677
STM1263
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75039.1); Blastp hit to AAC75039.1 (216 aa), 71% identity in aa 3 - 216.
       0.523
STM1265
Putative response regulators; Contains a CheY-like receiver domain and a HTH DNA-binding domain.
  
    0.521
folA
Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
      
 0.464
setB
Proton efflux pump; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose (By similarity); Belongs to the major facilitator superfamily. Set transporter family.
   
  
 0.458
gidB
Associated with glucose-inhibited division; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
      
 0.451
yhhJ
Putative ABC superfamily transport protein; Atp_bind/membrane; similar to E. coli putative transporter (AAC76510.1); Blastp hit to AAC76510.1 (375 aa), 92% identity in aa 2 - 375.
      
 0.450
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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