STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yeaCPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74847.1); Blastp hit to AAC74847.1 (105 aa), 87% identity in aa 16 - 105. (92 aa)    
Predicted Functional Partners:
yeaA
Hypothetical protein; Putative domain frequently associated with peptide methionine sulfoxide reductase; similar to E. coli orf, hypothetical protein (AAC74848.1); Blastp hit to AAC74848.1 (137 aa), 85% identity in aa 1 - 137.
  
    0.968
STM0437
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73748.1); Blastp hit to AAC73748.1 (184 aa), 38% identity in aa 61 - 150, 32% identity in aa 22 - 151, 36% identity in aa 57 - 131, 38% identity in aa 123 - 175, 30-1073758628dentity in aa 105 - 164, 22% identity in aa 10 - 129.
      
 0.950
yeaD
Putative enzyme related to aldose 1-epimerase; Probably functions as a hexose-6-phosphate 1-epimerase.
     
 0.871
sdhD
Succinate dehydrogenase, hydrophobic subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
    0.795
yhgI
Putative thioredoxin-like proteins and domain protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
     0.731
miaE
Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA; Production of the modified nucleoside 2-methylthio-cis- ribozeatin (MS[2]IO[6]A) found in some tRNAs. Catalyzes the oxygen- dependent transformation of MS[2]I[6]A into MS[2]IO[6]A.
  
     0.722
sdhC
Succinate dehydrogenase, cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
    0.716
tdcC
HAAAP family L-threonine/ L-serine permease; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
      
 0.699
tdcE
Pyruvate formate-lyase 4; Similar to E. coli probable formate acetyltransferase 3 (AAC76149.1); Blastp hit to AAC76149.1 (746 aa), 93% identity in aa 1 - 741; 2-ketobutyrate formate-lyase.
      
 0.693
topA
DNA topoisomerase type I, omega protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, th [...]
  
     0.652
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.