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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spySimilar to E. coli periplasmic protein related to spheroblast formation (AAC74813.1); Blastp hit to AAC74813.1 (161 aa), 89% identity in aa 1 - 161. (161 aa)    
Predicted Functional Partners:
yebE
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC74916.1); Blastp hit to AAC74916.1 (219 aa), 86% identity in aa 1 - 217.
  
  
 0.952
mdtA
Putative HlyD family secretion protein; Similar to E. coli putative membrane protein (AAC75135.1); Blastp hit to AAC75135.1 (464 aa), 82% identity in aa 50 - 464; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
   
  
 0.940
yegN
Putative outer membrane receptor; Similar to E. coli orf, hypothetical protein (AAC75136.1); Blastp hit to AAC75136.1 (1040 aa), 91% identity in aa 1 - 1040; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
   
  
 0.897
baeR
OmpR family; similar to E. coli transcriptional response regulatory protein (sensor BaeS) (AAC75140.1); Blastp hit to AAC75140.1 (240 aa), 96% identity in aa 1 - 240.
   
  
 0.817
yegO
Putative resistance protein; Efflux transporter; outer membrane; similar to E. coli orf, hypothetical protein (AAC75137.1); Blastp hit to AAC75137.1 (1025 aa), 91% identity in aa 1 - 1025; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
   
  
 0.785
htrA
Periplasmic serine protease Do, heat shock protein; DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolyt [...]
   
  
 0.779
sseB-2
Similar to E. coli enhanced serine sensitivity (AAC75575.1); Blastp hit to AAC75575.1 (261 aa), 90% identity in aa 1 - 261.
  
     0.769
ypfG
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75519.1); Blastp hit to AAC75519.1 (347 aa), 77% identity in aa 1 - 347.
  
    0.764
cpxR
Response reguator in two-component regulatory system with CpxA; Regulates expression of protein folding and degrading factors (OmpR family); similar to E. coli transcriptional regulator in 2-component system (AAC76894.1); Blastp hit to AAC76894.1 (232 aa), 97% identity in aa 1 - 232.
      
 0.761
ycfM
Putative outer membrane lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
  
    0.757
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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