Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ydiUPutative cytoplasmic protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). (480 aa)    
Predicted Functional Partners:
ybbB
Putative ATPase; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain (Probable); Belongs to the SelU family.
      
 0.911
ydiV
Putative diguanylate cyclase/phosphodiesterase domain 1; Acts as an anti-FlhC(2)FlhD(4) factor by binding to FlhD, decreasing its ability to bind DNA, and thus negatively regulates expression of flagellar class II operons, decreasing motility in nutrient-poor medium. Required for resistance to host phagocyte oxidase. Suppresses killing of macrophages, while promoting resistance to hydrogen peroxide. Data regarding c-di-GMP is controversial; suppresses bacterial c-di-GMP levels but neither synthesizes nor degrades c-di-GMP. Belongs to the YdiV family.
     
 0.868
btuC
Vitamin B12 transport protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.
    
 0.778
cfa
Similar to E. coli cyclopropane fatty acyl phospholipid synthase (AAC74733.1); Blastp hit to AAC74733.1 (382 aa), 90% identity in aa 1 - 382.
  
   
 0.729
STM1697
Putative diguanylate cyclase/phosphodiesterase domain 2; Similar to E. coli orf, hypothetical protein (AAC74777.1); Blastp hit to AAC74777.1 (237 aa), 29% identity in aa 17 - 189.
      
 0.726
yceA
Putative enzyme related to sulfur transferases; Similar to E. coli orf, hypothetical protein (AAC74139.1); Blastp hit to AAC74139.1 (350 aa), 88% identity in aa 1 - 350; Belongs to the UPF0176 family.
 
  
 0.675
btuE
Vitamin B12 transport protein; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.
  
 0.626
btuD
Vitamin B12 transport protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
  
  
 0.554
araJ
MFS family, arabinose polymer transporter; Similar to E. coli involved in either transport or processing of arabinose polymers (AAC73499.1); Blastp hit to AAC73499.1 (394 aa), 85% identity in aa 1 - 388.
      
 0.516
yeaA
Hypothetical protein; Putative domain frequently associated with peptide methionine sulfoxide reductase; similar to E. coli orf, hypothetical protein (AAC74848.1); Blastp hit to AAC74848.1 (137 aa), 85% identity in aa 1 - 137.
     
 0.461
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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