node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STM3859 | aroA | STM3859 | STM0978 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.896 |
STM3859 | aroB | STM3859 | STM3486 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.751 |
STM3859 | aroC | STM3859 | STM2384 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.754 |
STM3859 | aroD | STM3859 | STM1358 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. Belongs to the type-I 3-dehydroquinase family. | 0.967 |
STM3859 | aroE | STM3859 | STM3401 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | Dehydroshikimate reductase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.926 |
STM3859 | aroK | STM3859 | STM3487 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.966 |
STM3859 | aroL | STM3859 | STM0388 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | 0.977 |
STM3859 | menF | STM3859 | STM2310 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.878 |
STM3859 | ydiB | STM3859 | STM1359 | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | Putative shikimate 5-dehydrogenase; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | 0.945 |
aroA | STM3859 | STM0978 | STM3859 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | 0.896 |
aroA | aroB | STM0978 | STM3486 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.997 |
aroA | aroC | STM0978 | STM2384 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.999 |
aroA | aroD | STM0978 | STM1358 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. Belongs to the type-I 3-dehydroquinase family. | 0.657 |
aroA | aroE | STM0978 | STM3401 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Dehydroshikimate reductase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.970 |
aroA | aroK | STM0978 | STM3487 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.996 |
aroA | aroL | STM0978 | STM0388 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | 0.997 |
aroA | menF | STM0978 | STM2310 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.470 |
aroA | ydiB | STM0978 | STM1359 | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative shikimate 5-dehydrogenase; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | 0.978 |
aroB | STM3859 | STM3486 | STM3859 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Similar to E. coli dehydroshikimate reductase (AAC76306.1); Blastp hit to AAC76306.1 (272 aa), 26% identity in aa 20 - 258; quinate 5-dehydrogenase. | 0.751 |
aroB | aroA | STM3486 | STM0978 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.997 |