Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ydiMSimilar to E. coli putative transport system permease protein (AAC74760.1); Blastp hit to AAC74760.1 (404 aa), 79% identity in aa 1 - 395. (403 aa)    
Predicted Functional Partners:
ydiB
Putative shikimate 5-dehydrogenase; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
 
  
 0.939
aroD
3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. Belongs to the type-I 3-dehydroquinase family.
 
  
 0.874
STM2475
Putative cytoplasmic protein.
      
 0.851
yfcJ
Similar to E. coli putative transport protein (AAC75382.1); Blastp hit to AAC75382.1 (392 aa), 88% identity in aa 1 - 392.
      
 0.815
ydjM
LexA regulated gene; Putative SOS response; similar to E. coli orf, hypothetical protein (AAC74798.1); Blastp hit to AAC74798.1 (200 aa), 86% identity in aa 1 - 199.
   
  
 0.728
araJ
MFS family, arabinose polymer transporter; Similar to E. coli involved in either transport or processing of arabinose polymers (AAC73499.1); Blastp hit to AAC73499.1 (394 aa), 85% identity in aa 1 - 388.
      
 0.721
ycfJ
Putative outer membrane lipoprotein; Similar to E. coli orf, hypothetical protein (AAC74194.1); Blastp hit to AAC74194.1 (179 aa), 94% identity in aa 1 - 178.
      
 0.721
yhjE
Similar to E. coli putative transport protein (AAC76548.1); Blastp hit to AAC76548.1 (440 aa), 94% identity in aa 1 - 440.
   
  
 0.696
STM1269
Putative chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate.
   
  
 0.675
ynfM
Similar to E. coli putative transport protein (AAC74668.1); Blastp hit to AAC74668.1 (417 aa), 91% identity in aa 1 - 417.
      
 0.673
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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