STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sufBPutative ABC transporter; Similar to E. coli orf, hypothetical protein (AAC74753.1); Blastp hit to AAC74753.1 (508 aa), 96% identity in aa 14 - 508. (495 aa)    
Predicted Functional Partners:
sufC
Putative transport protein; ABC superfamily (atp_bind); similar to E. coli putative ATP-binding component of a transport system (AAC74752.1); Blastp hit to AAC74752.1 (248 aa), 92% identity in aa 1 - 248.
 
 0.999
sufD
Iron-sulfur component of FhuF stability protein; Similar to E. coli orf, hypothetical protein (AAC74751.1); Blastp hit to AAC74751.1 (423 aa), 79% identity in aa 1 - 421.
 
0.999
sufS
Selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
 
 0.999
sufA
Putative HesB-like domain protein; Similar to E. coli orf, hypothetical protein (AAC74754.1); Blastp hit to AAC74754.1 (122 aa), 84% identity in aa 1 - 122; Belongs to the HesB/IscA family.
 
 0.996
ynhA
Putative SufE protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family.
 
 0.994
csdA
Putative selenocysteine lyase; Similar to E. coli orf, hypothetical protein (AAC75852.1); Blastp hit to AAC75852.1 (401 aa), 89% identity in aa 1 - 401.
 
 0.967
nifU
NifU homolog; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
  
 0.910
yfhF
Putative regulator; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
  
 
 0.834
ygdK
Putative SufE protein probably involved in Fe-S center assembly; Similar to E. coli orf, hypothetical protein (AAC75853.1); Blastp hit to AAC75853.1 (147 aa), 88% identity in aa 1 - 144.
 
 
 0.759
yadR
Putative HesB-like domain protein; Required for insertion of 4Fe-4S clusters for at least IspG.
  
 
 0.727
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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