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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ttrSTetrathionate reductase complex: sensory transduction histidine kinase; Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase. Probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue in response to tetrathionate, and transfers its phosphate group to TtrR. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. (592 aa)    
Predicted Functional Partners:
ttrR
Tetrathionate reductase complex: response regulator; Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase. Positively regulates transcription of the ttrBCA operon. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.
 0.999
ttrC
Tetrathionate reductase complex, subunit C; Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrC probably anchors TtrA and TtrB to the periplasmic face of the cytoplasmic membrane. May transfer electrons from membrane quinol to TtrB. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. Belongs to the NrfD family.
 
   
 0.990
ttrA
Tetrathionate reductase complex, subunit A; Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrA is the catalytic subunit. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
 
  
 0.988
ttrB
Tetrathionate reductase complex, subunit B; Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrB is probably involved in transfer of electrons from TtrC to TtrA. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.
 
   
 0.960
hiuH
Putative periplasmic or exported protein; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
   
  
 0.892
arcB
Sensory histidine kinase in two-component regulatory system with ArcA; Senses redox conditions; similar to E. coli aerobic respiration sensor-response protein; histidine protein kinase/phosphatase, sensor for arcA (AAC76242.1); Blastp hit to AAC76242.1 (776 aa), 93% identity in aa 1 - 776.
 
 
 0.824
barA
Sensory histidine kinase; Similar to E. coli sensor-regulator, activates OmpR by phophorylation (AAC75828.1); Blastp hit to AAC75828.1 (918 aa), 90% identity in aa 1 - 918.
 
 
 0.756
flgD
Flagellar biosynthesis protein; Required for flagellar hook formation. May act as a scaffolding protein; Belongs to the FlgD family.
   
    0.752
pgtA
Activator protein; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. When activated by PgtB it acts in conjunction with sigma-54 as a transcriptional activator.
 
 
 0.728
hydG
Response regulator in two-component reguatory system with HydH; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity).
 
 
 0.725
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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