Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
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[Homology]
Score
ssaCSecretion system apparatus protein; SpiA (gi|1498307). (497 aa)    
Predicted Functional Partners:
ssaD
Secretion system apparatus protein; SpiB (gi|1498308).
  
  
 0.998
ssaJ
Secretion system apparatus protein; Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB toxin.
 
 
 0.998
ssaT
Secretion system apparatus protein; Part of a type III secretion system; Belongs to the FliR/MopE/SpaR family.
 
 
 0.990
ssrA
Secretion system regulator: Sensor component; SpiR (gi|1498305).
 
  
 0.979
ssaL
Secretion system apparatus protein SSAL. (SW:SSAL_SALTY).
  
  
 0.975
ssaB
Secretion system apparatus protein; Virulence protein that plays a central role in mammalian macrophage infection, by inhibiting phagosome-lysosome fusion and cellular trafficking. May act by disrupting the function of the mammalian HOOK3 protein, a protein involved in the cellular traffic.
  
  
 0.973
ssaR
Homology with YscR of the secretion system of Yersinia; virulence protein yscr (SW:YSCR_SALTY).
 
 
 0.969
ssaU
Secretion system apparatus protein; Part of a type III secretion system; Belongs to the type III secretion exporter family.
 
  
 0.962
ssaE
Secretion system effector; Putative secretory apparatus component (gi|3377860).
  
  
 0.959
sseD
Secretion system effector; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells.
  
  
 0.959
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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