STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ydhDPutative glutaredoxin protein; Similar to E. coli orf, hypothetical protein (AAC74726.1); Blastp hit to AAC74726.1 (115 aa), 97% identity in aa 1 - 115; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa)    
Predicted Functional Partners:
bolA
Morphogene; Similar to E. coli possible regulator of murein genes (AAC73538.1); Blastp hit to AAC73538.1 (116 aa), 92% identity in aa 12 - 116; Belongs to the BolA/IbaG family.
 
 
 0.939
ubiA
P-hydroxybenzoate: octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
 
     0.856
slyA
MarR family transcriptional regulator for hemolysin; Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.
 
 
    0.829
yhgI
Putative thioredoxin-like proteins and domain protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
 0.777
STM1790
Putative thiol-disulfide isomerase and thioredoxin; Similar to E. coli processing of HyaA and HyaB proteins (AAC74061.1); Blastp hit to AAC74061.1 (132 aa), 72% identity in aa 1 - 125.
   
  
 0.775
grxC
Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
 
 
 0.735
ubiH
2-octaprenyl-6-methoxyphynol hydroxylase; Similar to E. coli 2-octaprenyl-6-methoxyphenol--> 2-octaprenyl-6-methoxy-1, 4-benzoquinone (AAC75945.1); Blastp hit to AAC75945.1 (392 aa), 79% identity in aa 1 - 392.
  
     0.679
yfgD
Similar to E. coli putative oxidoreductase (AAC75548.1); Blastp hit to AAC75548.1 (119 aa), 83% identity in aa 1 - 119.
   
  
 0.678
yrbA
Putative BolA family transcriptional regulator; Similar to E. coli orf, hypothetical protein (AAC76222.1); Blastp hit to AAC76222.1 (89 aa), 95% identity in aa 3 - 89; Belongs to the BolA/IbaG family.
 
 
 
 0.665
yadR
Putative HesB-like domain protein; Required for insertion of 4Fe-4S clusters for at least IspG.
 
 0.648
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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