Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ydgAPutative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74686.1); Blastp hit to AAC74686.1 (502 aa), 79% identity in aa 1 - 502. (502 aa)    
Predicted Functional Partners:
manA
Mannose-6-phosphate isomerase; Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide; Belongs to the mannose-6-phosphate isomerase type 1 family.
 
    0.861
yedA
Similar to E. coli putative transmembrane subunit (AAC75025.1); Blastp hit to AAC75025.1 (306 aa), 89% identity in aa 1 - 298.
      
 0.859
ycfM
Putative outer membrane lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
  
  
 0.794
yojN
Putative sensor/kinase in regulatory system; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB.
  
     0.770
ydbH
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74463.1); Blastp hit to AAC74463.1 (879 aa), 78% identity in aa 1 - 878.
  
     0.766
STM1484
Putative protease; Similar to E. coli orf, hypothetical protein (AAC74670.1); Blastp hit to AAC74670.1 (273 aa), 77% identity in aa 1 - 272; Belongs to the peptidase S1B family.
  
    0.763
asmA
Similar to E. coli suppressor of ompF assembly mutants (AAC75125.1); Blastp hit to AAC75125.1 (617 aa), 76% identity in aa 1 - 617.
  
     0.763
ftsN
Essential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
  
     0.756
tonB
TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific en [...]
  
    0.729
slt
Soluble lytic murein transglycosylase; Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity).
  
     0.695
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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